麗澤通氣湯이 ovalbumin에 의하여 유발된 allergic mouse의 면역기능에 미치는 影響
Influences on immune function of allergic mouse induced by ovalbumin of Yeotaectonggitang(YTT)
- 주제(키워드) 여택통기탕 , ovalbumin , allergic mouse
- 발행기관 東新大學校 大學院
- 발행년도 2005
- 학위명 석사
- 학과 한의학과
초록/요약
Objective: This study was performed to investigate the effects of YTT on allergic bronchial asthma. Methods: The mice were divided into 4 groups induced the allergic bronchial asthma : Three groups(YTT-1, YTT-2, YTT-3) treated YTT and non-treated group(Control). Three oral administration of the herbal solution of YTT were carried out 1 time a day for 2 weeks before antigen sensitization. 2 days later, the mice were sensitized with a subcutaneous injection of ovalbumin(OA) and then 13 days later they were provoked with OA aerosols. Then the cell numbers in bronchoalveolar lavage fluid(BALF), serum level of IgE, WBC, RBC and HGB were measured. Results: 1. On the neutrophil in BALF, groups of YTT-2 and YTT-3 are significantly increased compared with the control group. 2. On the eosinophil in BALF, groups of YTT-1 and YTT-3 are significantly decreased compared with the control group. 3. On the lymphocyte in BALF, YTT-3 group is significantly increased compared with the control group. 4. On the macrophage in BALF, groups of YTT-1 and YTT-3 groups tend to increase. 5. On the serum IgE, groups YTT-1, YTT-2 and YTT-3 are significantly decreased compared with the control group. 6. On WBC in blood, groups of YTT-2, YTT-3 are significantly decreased compared with the control group. Conclusions: Based on the above results, it is assumed that the oral administration of YTT can help the treatment of allergic bronchial asthma.
more목차
목차 = i
ABSTRACT = ⅰ
Ⅰ. 서론 = 1
Ⅱ. 재료 및 방법 = 3
1. 재료 = 3
1)동물 = 3
2)약재 = 3
2. 방법 = 5
1) 검액의 조제 = 5
2) 실험군 분류 = 5
3) 경구투여 = 5
4) 감작, 유발 및 채혈 = 5
5) 혈액 검사 및 혈청 분리 = 6
6) 기관지폐포세척술 및 혈구 조사 = 6
7) 혈청 IgE 측정 = 7
3. 통계처리 = 8
Ⅲ. 성적 = 9
1. BALF 내 Neutrophil 변화 = 9
2. BALF 내 Eosinophil 변화 = 10
3. BALF 내 Lymphocyte 변화 = 11
4. BALF 내 Macrophage 변화 = 12
5. 혈청 IgE 변화 = 13
6. 혈액내 WBC, RBC, HGB 변화 = 14
Ⅳ. 고찰 = 16
Ⅴ. 결론 = 21
참고문헌 = 22