勻氣散이 흰쥐의 국소뇌혈류량 및 평균혈압에 미치는 효과
Effect of Kyungisan in on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats
초록/요약
Kyungisan(KGS) has been used in oriental medicine for many centuries as a therapeutic agent for stroke caused by deficiency of qi(氣虛). This study was performed to evaluate effects of KGS extract on the regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP) in rats. The result of this study were as follow ; 1. KGS significantly increased rCBF irrelevant to MABP in normal rats. 2. To prescribe KGS after pretreatment with indomethacin(IDN) decreased rCBF as compared with control group to administered only KGS in normal rats. But the change of MABP is not significantly as compared with control group. 3. To prescribe KGS after pretreatment with methylen blue(MTB) decreased MABP and rCBF as compared with control group to administered only KGS in normal rats. Especially, it significantly decreased rCBF. These results suggest that KGS increase rCBF by enlargement diameter of pial artery in brain. The active mechanism of KGS is related with prostaglandin activated by cyclooxygenase. So, I suggest that KGS has an anti-ischemic effect through the improvement of cerebral blood flow and can be used for stroke.
more목차
목차 = ⅰ
ABSTRACT = ⅲ
Ⅰ. 서론 = 1
Ⅱ. 材料 및 方法 = 3
1. 재료 = 3
1) 동물 = 3
2) 약재 = 3
2. 방법 = 5
1) 추출물의 제조 = 5
2) 국소뇌혈류량 (regional cerebral blood flow, rCBF) 측정 = 5
3) 평균혈압 (mean arterial blood pressure, MABP) 측정 = 5
4) rCBF 및 MABP 변화 기전 확인 = 6
3. 통계처리 = 6
Ⅲ. 實驗成績 = 7
1. KGS가 rCBF에 미치는 효과 = 7
2. KGS가 MABP에 미치는 효과 = 9
3. IDN 전처치 후 KGS 투여로 변화된 rCBF에 미치는 효과 = 11
4. IDN 전처치 후 KGS 투여로 변화된 MABP에 미치는 효과 = 13
5. MTB 전처치 후 KGS 투여로 변화된 rCBF에 미치는 효과 = 15
6. MTB 전처치 후 KGS 투여로 변화된 MABP에 미치는 효과 = 17
Ⅳ. 고찰 = 19
Ⅴ. 結論 = 24
參考文獻 = 25