大補元煎의 腦血流 增加效果에 대한 實驗的 硏究
(The) Experimental Study to Effects of Daebowon-Jeon on the Changes of Cerebral Blood Flow
초록/요약
This study was designed to investigate the effects of Daebowon-Jeon extract(DBWJ) on the change of cerebral hemodynamics [regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP)] in normal and to determine the mechanism of action of DBWJ. The results were as follows; 1. DBWJ significantly increased rCBF in a dose-dependent manner, but MABP was not changed by injecting DBWJ. 2. The DBWJ-induced increase in rCBF was significantly inhibited from pretreatment with indomethacin ( 1 ㎎/㎏, i.p.), an inhibitor of guanyl cyclase. 3. The DBWJ-induced didn't affect to reduce MABP by pretreatment with indomethacin and methylene blue. These results suggest that the mechanism of effect of DBWJ was mediated by cyclooxygenase, and had an effect of the improvement of cerebral hemodynamics.
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目次
ABSTRACT = ⅰ
Ⅰ. 서론 = 1
Ⅱ. 재료 및 방법 = 3
1. 재료 = 3
1) 동물 = 3
2) 약재 = 3
2. 방법 = 4
1) 검액의 제조 = 4
2) 정상 흰쥐의 뇌혈류역학 변동 관찰 = 4
① 국소 뇌혈류량 측정 = 4
② 평균 혈압 측정 = 4
3) 정상 흰쥐의 뇌혈류역학 변동에 미치는 기전 관찰 = 5
3. 통계분석 = 6
Ⅲ. 실험성적 = 7
1. DBWJ가 정상 흰쥐의 뇌혈류역학에 미치는 효과 = 7
1) DBWJ가 국소 뇌혈류량 변화에 미치는 영향 = 7
2) DBWJ가 평균 동맥혈압에 미치는 영향 = 9
2. 정상 흰쥐에서의 DBWJ에 의한 뇌혈류역학 변동기전 관찰 = 11
1) 정상 흰쥐에서의 DBWJ에 의한 rCBF 변동기전 관찰 = 11
① indomethacin 전처치후 DBWJ에 의한 rCBF 변화 = 11
② Methylene blue 전처치후 DBWJ에 의한 rCBF 변화 = 13
2) 정상 흰쥐에서의 DBWJ에 의한 MABP 변동기전 관찰 = 15
① indomethacin 전처치 후 DBWJ에 의한 rCBF 변화 = 15
② methylene blue 전처치 후 DBWJ에 의한 MABP 변화 = 17
Ⅳ. 考察 = 19
Ⅴ. 결론 = 22
참고문헌 = 23