六君子湯과 竹歷혼합물이 국소 뇌혈류량 및 평균혈압에 미치는 효과
Effects of mixture of Yukgunja-tang and bambusae caulis in liquamen on the regional cerebral blood flow and mean arterial blood pressure in rats
초록/요약
The study was designed to investigate the effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen (YTBCL) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats, and further to determine the mechanism of action of YTBCL. The results in rats were as follows ; 1. YTBCL 25 ㎕ significantly decreased rCBF and MABP compared with basal condition. 2. YTBCL 100 ㎕ significantly increased rCBF compared with basal condition, but decreased MABP compared with basal condition. 3. YTBCL 50 ㎕ significantly increased rCBF compared with basal condition, but MABP was somewhat decreased compared with basal condition. 4. The YTBCL 50 ㎕-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ㎍/㎏, i.p.), an inhibitor of guanylate cyclase and indomethacin (1 ㎎/㎏, i.p.), an inhibitor of cyclooxygenase. 5. The YTBCL 50 ㎕-induced decreased MABP significantly increased by pretreatment with methylene blue but was inhibited by indomethacin. This results were suggested that the mechanism of YTBCL was mediated by guanylate cyclase.
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목차
ABSTRACT = ⅰ
Ⅰ. 서론 = 1
Ⅱ. 재료 및 방법 = 3
1. 재료 = 3
1) 동물 = 3
2) 시료 = 3
2. 방법 = 4
1) 시료의 조제 = 4
2) 뇌혈류역학 변화 관찰 = 6
3) 뇌혈류역학 변화에 미치는 기전 관찰 = 7
3. 통계처리 = 7
Ⅲ. 실험성적 = 8
1. YTBCL 25 ㎕의 혼합물이 국소 뇌혈류량 및 평균 혈압에 미치는 효과 = 8
2. YTBCL 50 ㎕의 혼합물이 국소 뇌혈류량 및 평균 혈압에 미치는 효과 = 10
3. YTBCL 100 ㎕의 혼합물이 국소 뇌혈류량 및 평균 혈압에 미치는 효과 = 12
4. YTBCL 50 ㎕의 혼합물이 국소 뇌혈류량에 미치는 작용기전 관찰 = 14
5. YTBCL 50 ㎕의 혼합물이 평균혈압에 미치는 작용기전 관찰 = 16
Ⅳ. 고찰 = 18
Ⅴ. 결론 = 23
참고문헌 = 24